PacBio was founded in 2004 to develop sequencing methods based on work done in the labs of biophysicist Watt Webb and engineer Harold Craighead, both at Cornell University. The previous year, the two had collaborated to create zero-mode waveguides (ZMWs): small containers just big enough to hold a single DNA polymerase and containing tiny holes at the bottom through which light could be detected. They were able to fix a DNA polymerase to the bottom of a ZMW and detect the incorporation of individual fluorescent “C” nucleotides through the holes, which fed into a microscope capable of detecting light emissions.
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关于这些隐私数据，这两天还有一篇论文在 X 上非常火，讲的其实就是老生常谈的问题，这些 AI 大模型如何使用我们的对话数据。，这一点在体育直播中也有详细论述
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This acceleration requires specifications: precise descriptions of what the software must do. As AI takes over implementation, specification becomes the core engineering discipline. Writing a specification forces clear thinking about what a system must do, what invariants it must maintain, what can go wrong. This is where the real engineering work has always lived. Implementation just used to be louder.