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Crucially, this distribution of border points is agnostic of routing speed profiles. It’s based only on whether a road is passable or not. This means the same set of clusters and border points can be used for all car routing profiles (default, shortest, fuel-efficient) and all bicycle profiles (default, prefer flat terrain, etc.). Only the travel time/cost values of the shortcuts between these points change based on the profile. This is a massive factor in keeping storage down – map data only increased by about 0.5% per profile to store this HH-Routing structure!

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Different types of lipid molecule are transported around the cell by lipid-transfer proteins. Biochemical approaches have been adapted to measure which lipids are captured by the more than 130 known human lipid-transfer proteins, providing a valuable resource that reveals some principles of how these transporters work.